STEM CELLS TRANSPLANTATION FOR MYOCARDIAL REGENERATION http://www.scielo.org.co
Heart failure is a heterogeneous clinical syndrome that is developed subsequent to an " index event", the one which produces damage of the cardiac tissue, for the lost of cardiomyocytes or by the alteration of the capacity of the myocardium to generate an efficient force for the ventricular contraction. The initial injury can be of sudden appearance as in the acute coronary syndrome or gradual as in the chronic coronary heart disease. Independent of the factor that generate the syndrome, is produced a series of hemodynamic alterations and neurohormonals responses with complex molecular changes, that lead to the progression of the ventricular dysfunction and to a greater loss of contractile cells.
The therapeutic strategies developed to interrupt this vicious circle of ventricular remodeling, only change the conditions of the myocardial work, with the consequent improvement in the quality of life and in mortality. However, this therapeutic approach does not produce myocardial regeneration, what permits the progression of the disease until terminal heart failure and death.
Experimental and clinical studies have shown that the implantation of bone marrow stem cells produce angiogenesis and improves cardiac function in patients with acute and chronic ischaemic heart disease. This therapy produces meaningful improvement in symptoms, exercise capacity, in the functional state, in the size of the myocardial perfusion defect by nuclear medicine, in the ejection fraction and decrease of the end-systolic volume of the left ventricle, without complications related with the procedure.
Conclusion: The bone marrow stem cells transplantation is an effective and safe therapy to promote neovascularization and improve perfusion and myocardial contractility in patients with acute and chronic ischaemic heart disease and no other option for standard revascularization therapies.
Heart failure is a heterogeneous clinical syndrome that is developed subsequent to an " index event", the one which produces damage of the cardiac tissue, for the lost of cardiomyocytes or by the alteration of the capacity of the myocardium to generate an efficient force for the ventricular contraction. The initial injury can be of sudden appearance as in the acute coronary syndrome or gradual as in the chronic coronary heart disease. Independent of the factor that generate the syndrome, is produced a series of hemodynamic alterations and neurohormonals responses with complex molecular changes, that lead to the progression of the ventricular dysfunction and to a greater loss of contractile cells.
The therapeutic strategies developed to interrupt this vicious circle of ventricular remodeling, only change the conditions of the myocardial work, with the consequent improvement in the quality of life and in mortality. However, this therapeutic approach does not produce myocardial regeneration, what permits the progression of the disease until terminal heart failure and death.
Experimental and clinical studies have shown that the implantation of bone marrow stem cells produce angiogenesis and improves cardiac function in patients with acute and chronic ischaemic heart disease. This therapy produces meaningful improvement in symptoms, exercise capacity, in the functional state, in the size of the myocardial perfusion defect by nuclear medicine, in the ejection fraction and decrease of the end-systolic volume of the left ventricle, without complications related with the procedure.
Conclusion: The bone marrow stem cells transplantation is an effective and safe therapy to promote neovascularization and improve perfusion and myocardial contractility in patients with acute and chronic ischaemic heart disease and no other option for standard revascularization therapies.
2 comentarios:
Hola Dr, lo felicito por su blog, me parece super la transferencia de conocimiento. Este procedimiento ya se realiza en Colombia???
Un abrazo y felicitaciones my president¡¡
Juan Manuel , como te comente antes me parece un blog muy didactico, altamente cientifico y muy bien ilustrado. Por lo cual mil felicitaciones. Creo que para el gremio medico y los cardilogos es una herramienta indiscutible de la vida moderna que hay que aprovechar.
Un fuerte abrazo.
Javier Correa Alvarez
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